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KMID : 0365819640040010045
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Journal of Pusan Medical College
1964 Volume.4 No. 1 p.45 ~ p.51
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Effect of Procaine Hydrochloride on Wound Healing
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Abstract
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The use of procaine hydrochloride for the treatment of the various inflammatory diseases has been widely practiced in our clinic, and prior to the present experiment, author made a study of the effect of prociane on allergic cholecystitis and bacteriological suppurative inflammation of skin induced in rabbits experimentally.
Although repair is sometimes spoken of as a part of inflammation, the two processes go on side by side, but they are quite independent of one another, and either may be absent. Author therefore undertook the present experiment to observe the effect of procaine on wound healing.
To observe the effect of procaine on repair process, wounds either incised without loss of substance or opened with loss of substance were made surgically on the abdomen of rabbits.
In the first series of the experiment, eight incised wounds of I c m in length with depth down to musculocutaneus were made on abdomen of each rabbit and then on the following; 4th, 5th, 6th, 7th, 8th, 9th, 10th, and 11th past-wound day, each wound was observed for the adaptability of-wound edges by splicing test with author´s´ fingers.
In the 2nd series of the experiment, 8 incised wounds on each rabbit were male same as the 1st series, and then on the following 1st, 2nd, 3rd, 4th, 5th, 6th, 7th, and 8th post-wound day, tissue specimen of each skin wound was taken for patho-histological study..
In the 3rd series one open wound of I square cm with depth down to musculucutaneus
was made in the center.. of the abdomen of each rabbit, and the process of wound healing
and the length of period of complete healing were observed.
In each 3 series of the experiment above, the animals were subdivided into 3 groups:
Group A: Wounds were made only.
Group B: Wounds were made, and Ringer´s solution of 10 cc/Kg of body wt. was
infiltrated around the wounds for the control.
Group C: Wounds were made and 10 cc/Kg of body wt. of procaine of 0.25 was
infiltrated around the wounds.
Result:
In the first series, each around of upto the 10th post-wound day could be split with fingers, but the 11th day wound withstood the splitting test, in Group A,& B, while in Group C the 9th day wound withstood it, in average.
In the 2nd series, patho-histological study revealed less vascular reactions and more formation and proliferation of fibroblasts and fibrils in Group C than in Group A, & B.
In the 3rd series, the open wound healed up, is average,at the end of the 8th post-wound day in Group C and at the end of the average 10th post-wound day in Group A, & B.
In conclusion, the effect of procaine hydrochloride on wound healing is summarized as follows:
1) Procaine hydrochloride is able to accelerate the rate of wound healing.
2) Procaine accelerates the absorption of the disintegration products and cellular debris
which act as "evocators" of the exudate is the wound, and therefore it shortens the exu
dative phase leading to accelerate ploriferation of fibroblasts and fibrils.
3) Procaine promotes the return of normal circulation in the damage tissue, thus accelerating absorption of cellular debris and inflammatory exudates in early stage of the wound.
4) Procaine prometes the increase of tensile strength of wound as well as formation of connective tissue in the process of repair.
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